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degU

two-component response regulator involved in control of biofilm, antibiotics and extracellular enzymes
genedegU
producttwo-component response regulator involved in control of biofilm, antibiotics and extracellular enzymes
locusRBAM_032640
synonyms
homologBSU35490
start3379813
stop3380502
direction-
length690
essential
Expressed protein
Standard condition
Genomic Context

Functional containing this gene/protein

CategoryInformation processing
Subcategory1regulation of gene expression
Subcategory2transcription factors and their control
Subcategory3two-component system response regulators

Phenotypes of a mutant

plant-bacteria interaction

root colonization, control of plant pathogens, 4. Lifestyles, 4.1. Exponential and early post-exponential lifestyles, 4.1.2. Biofilm formation, 4.1.2.4. Regulation

Expression and Regulation

Operons
degS-degU
Transcripts
Primary TSS3380516
Secondary TSS
Internal TSS
Antisense TSS3380138

Sigma factors

SigA

Protein regulator

CcpA activation DegU activation SinR repression TnrA repression

Additional regulation

Transcription of the bac operon and of the ywfH gene in B. amyloliquefaciens FZB42 was positively controlled by the DegU global regulator protein

RNA regulation_mode

This gene is a member of the following regulons

SigA Regulon
The protein


Catalyzed reaction/ biological activity
E.C. number
Protein family
Domains
Effectors of protein activity
Refer to BSU35490
Structure
Refer to BSU35490
Modification
Acetylation
"K97,181"
Localization

Biological materials


Mutant
LacZ fusion
GFP fusion
FLAG-tag construct
Antibody
Additional information
In Bacillus spp., the global transcription regulator DegU regulates flagellar motility, biofilm formation and antibiotic production (bacillomycin D, bacilysin)

References


Liu L, Wang G, Song L, Lv B, Liang W

Acetylome analysis reveals the involvement of lysine acetylation in biosynthesis of antibiotics in Bacillus amyloliquefaciens.

Sci Rep. 2016 Jan 29;6:20108. doi: 10.1038/srep20108;PMID:26822828

Xu Z, Zhang R, Wang D, Qiu M, Feng H, Zhang N, Sh

Enhanced control of cucumber wilt disease by Bacillus amyloliquefaciens SQR9 by altering the regulation of Its DegU phosphorylation.

Appl Environ Microbiol. 2014 May;80(9):2941-50. doi: 10.1128/AEM.03943-13. Epub 2014 Feb 28.;PMID:24584252

Dietel K, Beator B, Budiharjo A, Fan B, Borriss R

Bacterial Traits Involved in Colonization of Arabidopsis thaliana Roots by Bacillus amyloliquefaciens FZB42.

Plant Pathol J. 2013 Mar;29(1):59-66. doi: 10.5423/PPJ.OA.10.2012.0155;PMID:25288929

Mariappan A, Makarewicz O, Chen XH, Borriss R.

Two-component response regulator DegU controls the expression of bacilysin in plant-growth-promoting bacterium Bacillus amyloliquefaciens FZB42.

J Mol Microbiol Biotechnol. 2012;22(2):114-25. doi: 10.1159/000338804. Epub 2012 Jun 7;PMID:22677979

Scholz R, Molohon KJ, Nachtigall J, Vater J, Mark

"Plantazolicin, a novel microcin B17/streptolysin S-like natural product from Bacillus amyloliquefaciens FZB42."

J Bacteriol. 2011 Jan;193(1):215-24. doi: 10.1128/JB.00784-10. Epub 2010 Oct 22;PMID:20971906

Koumoutsi A, Chen XH, Vater J, Borriss R.

DegU and YczE positively regulate the synthesis of bacillomycin D by Bacillus amyloliquefaciens strain FZB42.

Appl Environ Microbiol. 2007 Nov;73(21):6953-64. Epub 2007 Sep 7.;PMID:17827323